CAG promoter (CMV-IE enhancer, chicken beta-actin promoter, rabbit beta-globin genomic DNA), mouse Aicda cDNA mAIDを全身で恒常的に発現する。 Backcross to C57BL/6 (Hemizygote x C57BL/6CrSlc) C（3〜6か月） Immunology and Inflammation Research 1) The RECIPIENT shall use the BIOLOGICAL RESOURCE only for academic research for the purpose of publishing the research results.<br>2) In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR and a citation of the following literature(s) designated by the DEPOSITOR are requested. J. Exp. Med., 197, 1173-1181 (2003).<br>3) RECIPIENT shall notify the PROVIDER upon filing a patent application claiming modification of the BIOLOGICAL RESOURCE or method(s) of manufacture or use(s) of the BIOLOGICAL RESOURCE. 条件を付加する。<br>1. 公表を前提とした学術研究に限る。<br>2. 研究成果の公表にあたって寄託者への謝辞の表明並びに寄託者の指定する文献を引用する。J. Exp. Med., 197, 1173-1181 (2003).<br>3. 本件リソースの改変体又は本件リソースの生産方法若しくは使用方法に係る特許を出願した場合、その旨を速やかに寄託者に通知する。 C (3-6 months) C57BL/6 マウスと交配し、系統維持している。 <a href='https://brc.riken.jp/mus/pcr00894'>Genotyping protocol -PCR-</a> Tasuku HONJO C57BL/6-Tg(CAG-Aicda)B1Hon/HonRbrc AID-Tg line #B1 AID-Tg line #B1 Necessary documents for ordering:<ol><li>Order form (<A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_4.docx">Japanese</A> / <A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_b.docx">English</A>)</li><li>Category I MTA: MTA for distribution with RIKEN BRC (<A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_5.docx">Japanese</A> / <A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_c.docx">English</A>)</li><li>CAGGS MTA (<A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/CAGGS_MTA.docx">English</A>)</li><li>Acceptance of responsibility for living modified organism (<A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_7.docx">Japanese</A> / <A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_g.docx">English</A>)</li></ol><A HREF="https://www2.mfour.med.kyoto-u.ac.jp/en/index.html" target="_blank">Honjo Lab HP</A> 京都大学 AID-Tg line #B1 本庶　佑 true AID, Activation-Induced cytidine Deaminase is a molecule which specifically expressed in B lymphocytes after antigen stimulation, and plays a central role in acquisition for B cell of antibody gene variety. The transgenic mice express mouse AID gene under the control of CAG promoter and show high incidence of T cell lymphomas and dysgenetic lesions of epithelium of respiratory bronchioles. Developed by Drs. Tasuku Honjo and Il-mi Okazaki at Kyoto University in 2002. 開発年：2002年 開発者：本庶佑先生、岡崎一美先生 機関名：京都大学大学院医学研究科・分子生物学 Kyoto Univ. 開発年：2002年開発者：本庶佑先生、岡崎一美先生機関名：京都大学大学院医学研究科・分子生物学 RBRC00894